Kirksville hotels are convenient and making traveling easy and this popular favorite is the closet hotel to two Universities, Truman and A.T. Still. Featuring all the amenities you would expect from a Holiday Inn Express, a hot breakfast, featuring an extended breakfast area, fitness room, indoor heated pool, guest laundry and a meeting room that can host 35 people. Your Holiday Inn Express is the newest, non-smoking, state of the art hotel in Kirksville. Our property boasts the absolute best service in town. If you are traveling for leisure or business, you deserve the best hotel in town. Coming into Kirksville, our staff can give you directions to Thousand Hills State Park, Missouri Conservation Center, Kraft Foods, Northeast Regional Medical Center and that’s just mentioning a few places.