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Cheap flights from Madrid to Panama City from £257

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Madrid to Panama City departing on 16/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap return flights

Avianca Logo
13:10 - 21:10MAD-PTY
15h 00m1 stop
Avianca Logo
22:05 - 23:30PTY-MAD
18h 25m1 stop
£485Avianca
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Mon, 15 Sep - Mon, 22 Sep
Avianca Logo
01:20 - 14:00MAD-PTY
18h 40m1 stop
Avianca Logo
02:55 - 23:20PTY-MAD
14h 25m1 stop
£488Avianca
Find Deal
Sat, 22 Nov - Fri, 28 Nov
Logo
17:10 - 16:50MAD-PTY
30h 40m1 stop
Logo
22:20 - 17:40PTY-MAD
13h 20m1 stop
£505
Find Deal
Wed, 10 Sep - Tue, 18 Nov
United Airlines Logo
11:15 - 13:50MAD-PTY
33h 35m2 stops
United Airlines Logo
16:41 - 09:15PTY-MAD
34h 34m2 stops
£507United Airlines
Find Deal
Thu, 9 Oct - Thu, 6 Nov
United Airlines Logo
11:15 - 17:07MAD-PTY
35h 52m2 stops
United Airlines Logo
23:55 - 08:00PTY-MAD
26h 05m2 stops
£510United Airlines
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Sat, 10 Jan - Sat, 24 Jan
Air Europa Logo
15:05 - 18:40MAD-PTY
10h 35mdirect
Air Europa Logo
20:25 - 13:15PTY-MAD
9h 50mdirect
£528Air Europa
Find Deal
Mon, 8 Sep - Sat, 27 Sep
Air Europa Logo
15:05 - 18:40MAD-PTY
10h 35mdirect
Air Europa Logo
20:25 - 13:15PTY-MAD
9h 50mdirect
£532Air Europa
Find Deal
Tue, 9 Sep - Wed, 24 Sep
Logo
20:25 - 16:50MAD-PTY
27h 25m1 stop
Logo
14:10 - 09:35PTY-MAD
36h 25m1 stop
£533
Find Deal
Fri, 12 Sep - Wed, 24 Sep
Delta Logo
10:05 - 12:55MAD-PTY
33h 50m1 stop
Delta Logo
14:10 - 07:50PTY-MAD
34h 40m2 stops
£564Delta
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Wed, 10 Sep - Fri, 26 Sep
Delta Logo
10:00 - 14:02MAD-PTY
34h 02m2 stops
Delta Logo
15:27 - 08:00PTY-MAD
34h 33m2 stops
£567Delta
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Fri, 9 Jan - Sun, 18 Jan

Air Europa flights from Madrid to Panama City

Our best Air Europa deals on Madrid to Panama City flight tickets
Air Europa
8 Sept
MAD15:05Madrid Barajas
10h 35m
PTY18:40Panama City Tocumen Intl
27 Sept
PTY20:25Panama City Tocumen Intl
9h 50m
MAD13:15Madrid Barajas
£528
Find similar
Air Europa
9 Sept
MAD15:05Madrid Barajas
10h 35m
PTY18:40Panama City Tocumen Intl
23 Sept
PTY20:25Panama City Tocumen Intl
9h 50m
MAD13:15Madrid Barajas
£532
Find similar
Air Europa
10 Oct
MAD15:05Madrid Barajas
10h 35m
PTY18:40Panama City Tocumen Intl
8 Nov
PTY21:30Panama City Tocumen Intl
9h 35m
MAD13:05Madrid Barajas
£534
Find similar

United Airlines flights from Madrid to Panama City

Our best United Airlines deals on Madrid to Panama City flight tickets
United Airlines
9 Oct
MAD11:15Madrid Barajas
33h 35m
2 stops
PTY13:50Panama City Tocumen Intl
6 Nov
PTY16:41Panama City Tocumen Intl
34h 34m
2 stops
MAD09:15Madrid Barajas
£507
Find similar
United Airlines
10 Jan
MAD11:15Madrid Barajas
35h 52m
2 stops
PTY17:07Panama City Tocumen Intl
24 Jan
PTY23:55Panama City Tocumen Intl
26h 05m
2 stops
MAD08:00Madrid Barajas
£510
Find similar
United Airlines
9 Oct
MAD11:15Madrid Barajas
33h 35m
2 stops
PTY13:50Panama City Tocumen Intl
9 Nov
PTY16:41Panama City Tocumen Intl
34h 34m
2 stops
MAD09:15Madrid Barajas
£512
Find similar

momondo Fare Finder

 
Customise your flight search to find flights from Madrid to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 279,928 searches. Data last updated 1 August 2025.
Use the filters below to find and compare flights from Madrid to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Mon 15/9

13:10-21:10

1 stop15h 00m

Panama City Tocumen Intl

Mon 22/9

22:05-23:30

1 stop18h 25m

£485

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Sat 22/11

01:20-14:00

1 stop18h 40m

Panama City Tocumen Intl

Fri 28/11

02:55-23:20

1 stop14h 25m

£488

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Wed 10/9

17:10-16:50

1 stop30h 40m

Panama City Tocumen Intl

Tue 18/11

22:20-17:40

1 stop13h 20m

£505

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Thu 9/10

11:15-13:50

2 stops33h 35m

Panama City Tocumen Intl

Thu 6/11

16:41-09:15

2 stops34h 34m

£507

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Sat 10/1

11:15-17:07

2 stops35h 52m

Panama City Tocumen Intl

Sat 24/1

23:55-08:00

2 stops26h 05m

£510

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Mon 8/9

15:05-18:40

Nonstop10h 35m

Panama City Tocumen Intl

Sat 27/9

20:25-13:15

Nonstop9h 50m

£528

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Tue 9/9

15:05-18:40

Nonstop10h 35m

Panama City Tocumen Intl

Wed 24/9

20:25-13:15

Nonstop9h 50m

£532

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Fri 12/9

20:25-16:50

1 stop27h 25m

Panama City Tocumen Intl

Wed 24/9

14:10-09:35

1 stop36h 25m

£533

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Wed 10/9

10:05-12:55

1 stop33h 50m

Panama City Tocumen Intl

Fri 26/9

14:10-07:50

2 stops34h 40m

£564

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Fri 9/1

10:00-14:02

2 stops34h 02m

Panama City Tocumen Intl

Sun 18/1

15:27-08:00

2 stops34h 33m

£567

Flights are sorted by cheapest return flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
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See travel insights to Panama City from

How to get the cheapest flight ticket from Madrid to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Madrid and Panama City?

What is the cheapest month to fly to Panama City?

If you aren’t able to travel to Panama City during the month of March, then flying in September is also cheap. Prices for this month can be found on momondo for an average of £517.

What is the cheapest day to depart on your flight to Panama City?

According to our data, Saturday is the cheapest day to fly to Panama City from Madrid. The lowest ticket price found for a Saturday departure recently was £601. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. On the other hand, Wednesday is the most expensive day to depart from Madrid because it is more convenient for both business and leisure travellers. As a result, prices tend to be around £988.

What is the cheapest time of day to depart on your flight to Panama City?

Flying to Panama City from Madrid in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as £601 when looking at flights departing in the afternoon. Flights to Panama City are more costly in the morning, with an average ticket price of £687. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Madrid Barajas to Panama City Tocumen Intl flight route?

Fly from Madrid Barajas to Panama City Tocumen Intl for the best Madrid Barajas - Panama City Tocumen Intl flight prices

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from Madrid when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around £605 when searching weeks before you fly. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Madrid for as low as £532 on momondo.

What cabin class options are available on Madrid Barajas to Panama City Tocumen Intl flights?

There are 3 cabin classes available to choose from on Madrid Barajas to Panama City Tocumen Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Madrid to Panama City flights?

You could potentially save up to 9% on your flight if you consider stops on a Madrid to Panama City flight.

How have Madrid to Panama City flight prices changed over time?

As of August 2025, prices for Madrid to Panama City flights are approximately 21% cheaper when compared to flights at the same time last year.

When to book flights from Madrid to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Madrid to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated return price

Cheap Madrid to Panama City (MAD to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Madrid to Panama City

Best price found

£257

Fastest flight time

10h 35m

Direct flights

Every day

Airports in Panama City

1 airport
The best one-way flight to Panama City from Madrid in the past 72 hours is £257. The best return flight deal from Madrid to Panama City found on momondo in the last 72 hours is £485.
The fastest flight from Madrid to Panama City takes 10h 35m
Direct flights go from Madrid to Panama City every day.
There is 1 airport near Panama City: Panama City Tocumen Intl (PTY)
Search flight deals

  • How far is Madrid Barajas to Panama City Tocumen Intl by plane?

    Panama City Tocumen Intl is 5069.0 mi away from Madrid Barajas. By plane, this route typically takes 10h 35m.

  • When did momondo last update prices for flights from Madrid Barajas Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Madrid Barajas Airport to Panama City Tocumen Intl Airport were last updated today.

  • How many operators does momondo search for flights from Madrid Barajas Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Madrid Barajas Airport to Panama City Tocumen Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Madrid Barajas Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The necessary travel and health documents for your Panama City Tocumen Intl Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Madrid to Panama City?

  • What is the most popular airline from Madrid to Panama City?

Best airlines flying from Madrid to Panama City

Compare and see reviews for airlines that fly from Madrid to Panama City with momondo
Airline
Rating
Free Cancellation
Price
Air EuropaPriceFrom £442Free CancellationRating
7.0
543 reviews
Search Air Europa flights
IberiaPriceFrom £545Free CancellationRating
7.0
2,859 reviews
Search Iberia flights

  • Air Europa Flights From Madrid to Panama City

    Air Europa flight deals from Madrid to Panama City start from £585 round-trip. Over the 8 Air Europa flights for this route in a normal week, average airfare is usually £701 round-trip - but some users have found much cheaper deals with momondo.

  • Iberia Flights From Madrid to Panama City

    Across 2,859 Iberia reviews on momondo, the average score is 7.0/10. Iberia flies from Madrid to Panama City about 4 times each week, with ticket deals ranging from £721 to £910. Price data is based on momondo searches in the last 72 hours.

Travelling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Madrid to Panama City?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Madrid to Panama City for you.

Can I find flights from Madrid to Panama City with flexible booking policies on momondo?

All flight searches from Madrid to Panama City on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Madrid to Panama City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Madrid to Panama City.

I’m not ready to book a flight from Madrid to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Madrid to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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Fly your favourite airline to Panama City

Airlines are sorted and displayed according to clicks in the past 7 days on momondo
British Airways
Ryanair
easyJet
Turkish Airlines
Emirates
Qatar Airways
Etihad Airways
Lufthansa
Virgin Atlantic
Pegasus Airlines
KLM
Air India