Cheap flights from Madrid to Panama City from £281

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Madrid to Panama City departing on 3/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap return flights

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Avianca Logo
06:35 - 01:00
MAD
-
PTY
24h 25m
1 stop
Avianca Logo
14:55 - 23:20
PTY
-
MAD
26h 25m
1 stop
£506Avianca
Sun, 8 Mar - Fri, 27 Mar
Avianca Logo
10:50 - 01:00
MAD
-
PTY
20h 10m
1 stop
Avianca Logo
02:55 - 23:20
PTY
-
MAD
14h 25m
1 stop
£510Avianca
Thu, 5 Mar - Tue, 17 Mar
Avianca Logo
06:35 - 16:55
MAD
-
PTY
16h 20m
1 stop
Avianca Logo
02:55 - 23:20
PTY
-
MAD
14h 25m
1 stop
£511Avianca
Tue, 10 Mar - Sun, 15 Mar
KLM Logo
06:00 - 16:50
MAD
-
PTY
17h 50m
1 stop
KLM Logo
18:50 - 16:25
PTY
-
MAD
14h 35m
1 stop
£522KLM
Wed, 10 Jun - Wed, 17 Jun
KLM Logo
10:25 - 16:50
MAD
-
PTY
37h 25m
1 stop
KLM Logo
18:50 - 23:25
PTY
-
MAD
21h 35m
1 stop
£525KLM
Fri, 1 May - Thu, 9 Jul
Air Europa Logo
15:05 - 18:40
MAD
-
PTY
10h 35mdirect
Air Europa Logo
20:25 - 13:15
PTY
-
MAD
9h 50mdirect
£529Air Europa
Thu, 21 May - Mon, 25 May
Air Europa Logo
15:05 - 18:40
MAD
-
PTY
10h 35mdirect
Air Europa Logo
20:25 - 13:15
PTY
-
MAD
9h 50mdirect
£532Air Europa
Sat, 9 May - Sun, 24 May
Avianca Logo
06:35 - 14:00
MAD
-
PTY
13h 25m
1 stop
Avianca Logo
02:55 - 23:20
PTY
-
MAD
14h 25m
1 stop
£533Avianca
Sun, 8 Mar - Sat, 14 Mar
Avianca Logo
10:50 - 08:50
MAD
-
PTY
28h 00m
1 stop
Avianca Logo
03:05 - 06:10
PTY
-
MAD
20h 05m
1 stop
£534Avianca
Wed, 11 Mar - Sat, 4 Apr
Air Europa Logo
15:05 - 18:40
MAD
-
PTY
10h 35mdirect
Air Europa Logo
20:25 - 13:15
PTY
-
MAD
9h 50mdirect
£535Air Europa
Sat, 6 Jun - Thu, 18 Jun

Avianca flights from Madrid to Panama City

Our best Avianca deals on Madrid to Panama City flight tickets
Avianca
8 Mar
MAD06:35Madrid Barajas
24h 25m
1 stop
PTY01:00Panama City Tocumen Intl
27 Mar
PTY14:55Panama City Tocumen Intl
26h 25m
1 stop
MAD23:20Madrid Barajas
£506
Avianca
5 Mar
MAD10:50Madrid Barajas
20h 10m
1 stop
PTY01:00Panama City Tocumen Intl
17 Mar
PTY02:55Panama City Tocumen Intl
14h 25m
1 stop
MAD23:20Madrid Barajas
£510
Avianca
10 Mar
MAD06:35Madrid Barajas
16h 20m
1 stop
PTY16:55Panama City Tocumen Intl
15 Mar
PTY02:55Panama City Tocumen Intl
14h 25m
1 stop
MAD23:20Madrid Barajas
£511

Air Europa flights from Madrid to Panama City

Our best Air Europa deals on Madrid to Panama City flight tickets
Air Europa
21 May
MAD15:05Madrid Barajas
10h 35m
PTY18:40Panama City Tocumen Intl
25 May
PTY20:25Panama City Tocumen Intl
9h 50m
MAD13:15Madrid Barajas
£529
Air Europa
9 May
MAD15:05Madrid Barajas
10h 35m
PTY18:40Panama City Tocumen Intl
24 May
PTY20:25Panama City Tocumen Intl
9h 50m
MAD13:15Madrid Barajas
£532
Air Europa
6 Jun
MAD15:05Madrid Barajas
10h 35m
PTY18:40Panama City Tocumen Intl
18 Jun
PTY20:25Panama City Tocumen Intl
9h 50m
MAD13:15Madrid Barajas
£535

momondo Fare Finder

 
Customise your flight search to find flights from Madrid to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 279,928 searches. Data last updated 1 February 2026.
Use the filters below to find and compare flights from Madrid to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Sun 8/3

06:35-01:00

1 stop24h 25m

Panama City Tocumen Intl

Fri 27/3

14:55-23:20

1 stop26h 25m

£506

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Thu 5/3

10:50-01:00

1 stop20h 10m

Panama City Tocumen Intl

Tue 17/3

02:55-23:20

1 stop14h 25m

£510

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Tue 10/3

06:35-16:55

1 stop16h 20m

Panama City Tocumen Intl

Sun 15/3

02:55-23:20

1 stop14h 25m

£511

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Wed 10/6

06:00-16:50

1 stop17h 50m

Panama City Tocumen Intl

Wed 17/6

18:50-16:25

1 stop14h 35m

£522

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Fri 1/5

10:25-16:50

1 stop37h 25m

Panama City Tocumen Intl

Thu 9/7

18:50-23:25

1 stop21h 35m

£525

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Thu 21/5

15:05-18:40

Nonstop10h 35m

Panama City Tocumen Intl

Mon 25/5

20:25-13:15

Nonstop9h 50m

£529

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Sat 9/5

15:05-18:40

Nonstop10h 35m

Panama City Tocumen Intl

Sun 24/5

20:25-13:15

Nonstop9h 50m

£532

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Sun 8/3

06:35-14:00

1 stop13h 25m

Panama City Tocumen Intl

Sat 14/3

02:55-23:20

1 stop14h 25m

£533

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Wed 11/3

10:50-08:50

1 stop28h 00m

Panama City Tocumen Intl

Sat 4/4

03:05-06:10

1 stop20h 05m

£534

MadridPanama City

MAD - PTY

MADPTY

Madrid Barajas

Sat 6/6

15:05-18:40

Nonstop10h 35m

Panama City Tocumen Intl

Thu 18/6

20:25-13:15

Nonstop9h 50m

£535

Flights are sorted by cheapest return flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Madrid to Panama City

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City?

If you aren’t able to travel to Panama City during the month of May, then flying in September is also cheap. Prices for this month can be found on momondo for an average of £514.

What is the cheapest day to depart on your flight to Panama City?

According to our data, Sunday is the cheapest day to fly to Panama City from Madrid. The lowest ticket price found for a Sunday departure recently was £496. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. On the other hand, Monday is the most expensive day to depart from Madrid because it is more convenient for both business and leisure travellers. As a result, prices tend to be around £1,332.

What is the cheapest time of day to depart on your flight to Panama City?

Flying to Panama City from Madrid in the morning is the least expensive time of day to depart. momondo users have found prices as low as £522 when looking at flights departing in the morning. Flights to Panama City are more costly in the afternoon, with an average ticket price of £580. Departure times in the afternoon fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Madrid Barajas to Panama City Tocumen Intl flight route?

Fly from Madrid Barajas to Panama City Tocumen Intl for the best Madrid Barajas - Panama City Tocumen Intl flight prices

How far in advance should I book a flight to Panama City?

You are more likely to see cheaper flights to Panama City from Madrid when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around £599 when searching weeks before you fly. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Madrid for as low as £524 on momondo.

What cabin class options are available on Madrid Barajas to Panama City Tocumen Intl flights?

There are 3 cabin classes available to choose from on Madrid Barajas to Panama City Tocumen Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Madrid to Panama City flights?

You could potentially save up to 41% on your flight if you consider stops on a Madrid to Panama City flight.

How have Madrid to Panama City flight prices changed over time?

As of February 2026, prices for Madrid to Panama City flights are approximately 14% more expensive when compared to flights at the same time last year.

When to book flights from Madrid to Panama City

Are you open to changing your travel dates? Check out the ideal times to fly from Madrid to Panama City according to our flight data. Find out which month and days have the cheapest flights.
Estimated return price

Cheap Madrid to Panama City (MAD to PTY) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Madrid to Panama City

Best price found

£506

Fastest flight time

10h 35m

Direct flights

Every day

Airports in Panama City

1 airport
The best flight deal from Madrid to Panama City found on momondo in the last 72 hours is £506
The fastest flight from Madrid to Panama City takes 10h 35m
Direct flights go from Madrid to Panama City every day.
There is 1 airport in Panama City. From Madrid there are direct flights to Panama City Tocumen Intl (PTY).
  • How far is Madrid Barajas to Panama City Tocumen Intl by plane?

    Panama City Tocumen Intl is 5069.0 mi away from Madrid Barajas. By plane, this route typically takes 10h 35m.

  • When did momondo last update prices for flights from Madrid Barajas Airport to Panama City Tocumen Intl Airport?

    Prices for flights from Madrid Barajas Airport to Panama City Tocumen Intl Airport were last updated today.

  • How many operators does momondo search for flights from Madrid Barajas Airport to Panama City Tocumen Intl Airport?

  • How old do you have to be to fly from Madrid Barajas Airport to Panama City Tocumen Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Madrid Barajas Airport to Panama City Tocumen Intl Airport.

  • What documentation or ID do you need to fly to Panama City Tocumen Intl Airport?

    The necessary travel and health documents for your Panama City Tocumen Intl Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Madrid to Panama City?

  • What is the most popular airline from Madrid to Panama City?

Best airlines flying from Madrid to Panama City

Compare and see reviews for airlines that fly from Madrid to Panama City with momondo
Airline
Rating
Free Cancellation
Price
Air EuropaPriceFrom £427Free CancellationRating
6.9
586 reviews
Search Air Europa flights
IberiaPriceFrom £506Free CancellationRating
7.0
3,100 reviews
Search Iberia flights
  • Iberia Flights From Madrid to Panama City

    Iberia flight deals from Madrid to Panama City start from £506 round-trip. Over the 3 Iberia flights for this route in a normal week, average airfare is usually £518 round-trip - but some users have found much cheaper deals with momondo.

  • Air Europa Flights From Madrid to Panama City

    Across 586 Air Europa reviews on momondo, the average score is 6.9/10. Air Europa flies from Madrid to Panama City about 6 times each week, with ticket deals ranging from £427 to £555. Price data is based on momondo searches in the last 72 hours.

Travelling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
San Blas

Why use momondo?

Why should I use momondo to find a flight deal from Madrid to Panama City?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Madrid to Panama City for you.

Can I find flights from Madrid to Panama City with flexible booking policies on momondo?

All flight searches from Madrid to Panama City on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Madrid to Panama City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Madrid to Panama City.

I’m not ready to book a flight from Madrid to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Madrid to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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1 adult
Tue 3/3
Tue 10/3

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