Cheap flights from Madrid to Santa Cruz de la Sierra from £349

The month of April is, on average, the cheapest month to fly to Santa Cruz de la Sierra from Madrid, with most prices found around £629. If you aren’t able to travel during the month of April, then book flights to Santa Cruz de la Sierra from Madrid during March instead. Flights to Santa Cruz de la Sierra in March, while not as cheap as those in April, still average around £634.

The cheapest day to depart on your flight to Santa Cruz de la Sierra is on a Friday when prices can be found for as low as £875. This is often the case because there is less demand to fly during this day of the week. The most expensive day to fly to Santa Cruz de la Sierra is Wednesday, with ticket prices averaging around £1,265.

The cheapest time of day to fly to Santa Cruz de la Sierra is at midday when flights can be purchased for as low as £967. In contrast, the most expensive time of day to depart to Santa Cruz de la Sierra is in the evening when prices are around £969.

Fly from Madrid Barajas to Santa Cruz de la Sierra Viru Viru Intl for the best Madrid Barajas - Santa Cruz de la Sierra Viru Viru Intl flight prices

You are more likely to see cheaper flights to Santa Cruz de la Sierra from Madrid when booking weeks ahead of your departure date. In general, you can expect to find flights to Santa Cruz de la Sierra for around £791 when searching weeks before you fly. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santa Cruz de la Sierra from Madrid for as low as £686 on momondo.

There are 2 cabin classes available to choose from on Madrid to Santa Cruz de la Sierra flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 42% on your flight if you consider stops on a Madrid to Santa Cruz de la Sierra flight.

As of September 2026, prices for Madrid to Santa Cruz de la Sierra flights are approximately 19% cheaper when compared to flights at the same time last year.

Historically, on average around 46% of flights between Madrid and Santa Cruz de la Sierra have experienced a delay on any given week. The average delay length over the past 12 months has been 129 minutes.

Generally, flights departing at night tend to experience fewer delays. Flights departing in the early afternoon have, in the past, seen delays more frequently in comparison.

Saturday is statistically the day of the week that experiences the fewest delays on this flight route. Thursday has historically seen more delays on average compared to the rest of the week.

According to our data, Air Europa have had the fewest delays on this route over the last 12 months, with about 37% of their flights experiencing any sort of delay.

The number of flights available between Madrid and Santa Cruz de la Sierra is 1 per day as of September 2026. The most frequent departure time is 14:00, with 85% of daily flights leaving in the afternoon.

As of September 2026, 8 flights take off from Madrid and land in Santa Cruz de la Sierra each week. The most common flight departure day for this route is Mon, with 38% of weekly flights taking off on this day.