Cheap flights from Madrid to Santa Cruz de la Sierra from £281

The month of March is, on average, the cheapest month to fly to Santa Cruz de la Sierra from Madrid, with most prices found around £667. If you aren’t able to travel during the month of March, then book flights to Santa Cruz de la Sierra from Madrid during September instead. Flights to Santa Cruz de la Sierra in September, while not as cheap as those in March, still average around £671.

The cheapest day to depart on your flight to Santa Cruz de la Sierra is on a Friday when prices can be found for as low as £839. This is often the case because there is less demand to fly during this day of the week. The most expensive day to fly to Santa Cruz de la Sierra is Wednesday, with ticket prices averaging around £1,336.

The cheapest time of day to fly to Santa Cruz de la Sierra is in the evening when flights can be purchased for as low as £1,016. In contrast, the most expensive time of day to depart to Santa Cruz de la Sierra is at midday when prices are around £1,336.

Fly from Madrid Barajas to Santa Cruz de la Sierra Viru Viru Intl for the best Madrid Barajas - Santa Cruz de la Sierra Viru Viru Intl flight prices

You are more likely to see cheaper flights to Santa Cruz de la Sierra from Madrid when booking weeks ahead of your departure date. In general, you can expect to find flights to Santa Cruz de la Sierra for around £816 when searching weeks before you fly. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santa Cruz de la Sierra from Madrid for as low as £723 on momondo.

There are 2 cabin classes available to choose from on Madrid Barajas to Santa Cruz de la Sierra Viru Viru Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 23% on your flight if you consider stops on a Madrid to Santa Cruz de la Sierra flight.

As of March 2026, prices for Madrid to Santa Cruz de la Sierra flights are approximately 9% cheaper when compared to flights at the same time last year.

Historically, on average around 45% of flights between Madrid and Santa Cruz de la Sierra have experienced a delay on any given week. The average delay length over the past 12 months has been 130 minutes.

Generally, flights departing at night tend to experience fewer delays. Flights departing in the early afternoon have, in the past, seen delays more frequently in comparison.

Saturday is statistically the day of the week that experiences the fewest delays on this flight route. Thursday has historically seen more delays on average compared to the rest of the week.

According to our data, Air Europa have had the fewest delays on this route over the last 12 months, with about 41% of their flights experiencing any sort of delay.

Bogotá (BOG) was the most common stop: 80% of momondo users choosing one-stop flights on this route connected there.

Flights via Bogotá (BOG) offer the lowest average return price of £715.

Flights connecting via Lima (LIM) have the shortest average one-way travel time: 20h 25m.

Bogotá (BOG) has the shortest average stopover time for this route: 4h 07m.