Cheap flights from Madrid to Santiago from £301

In general, May is the cheapest month to fly from Madrid to Santiago. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around £686. If you aren’t able to travel to Santiago during the month of May, then flying in March is also cheap. Prices for this month can be found on momondo for an average of £705.

The cheapest day to depart from Madrid to Santiago is on a Friday when prices can be found for as low as £888. Be sure to avoid booking your departure on a Monday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Monday is £988.

In the morning is the cheapest time of day to fly from Madrid to Santiago when you can find flight prices for as low as £896. Flying to Santiago in the morning is an ideal time because this is during off-peak travel hours. Flights to Santiago are more costly at midday, with an average ticket price of £983. Departure times at midday fall within the peak daily travel times, which is why tickets can be more expensive.

Fly from Madrid Barajas to Santiago Arturo Merino Benitez for the best Madrid Barajas - Santiago Arturo Merino Benitez flight prices

You are more likely to see cheaper flights to Santiago from Madrid when booking weeks ahead of your departure date. In general, you can expect to find flights to Santiago for around £833 when searching weeks before you fly. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Santiago from Madrid for as low as £745 on momondo.

There are 3 cabin classes available to choose from on Madrid to Santiago flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 36% on your flight if you consider stops on a Madrid to Santiago flight.

As of July 2026, prices for Madrid to Santiago flights are approximately 15% more expensive when compared to flights at the same time last year.

Historically, on average around 19% of flights between Madrid and Santiago have experienced a delay on any given week. The average delay length over the past 12 months has been 119 minutes.

Generally, flights departing at night tend to experience fewer delays. Flights departing in the early afternoon have, in the past, seen delays more frequently in comparison.

Saturday is statistically the day of the week that experiences the fewest delays on this flight route. Friday has historically seen more delays on average compared to the rest of the week.

According to our data, LATAM Airlines have had the fewest delays on this route over the last 12 months, with about 16% of their flights experiencing any sort of delay.

14 flights are operational daily from Madrid to Santiago as of July 2026. The most popular departure time for this route is 23:00, with 66% of flights per day taking off in the evening.

103 flights are operational weekly from Madrid to Santiago as of July 2026. The most popular departure day for this route is Mon, with 17% of flights per week taking off on this day.