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Cheap flights from Southampton to Santiago from £411

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Southampton to Santiago departing on 11/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags
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Find the cheapest flights from Southampton to Santiago

Cheap return flights

Enter your travel dates to find the best prices.
Delta Logo
17:45 - 07:40
SOU
-
SCL
40h 55m
2 stops
Delta Logo
20:40 - 08:45
SCL
-
SOU
55h 05m
2 stops
£1,104Delta
Sun, 22 Mar - Wed, 8 Apr
Delta Logo
08:50 - 07:40
SOU
-
SCL
25h 50m
2 stops
Delta Logo
20:40 - 08:45
SCL
-
SOU
55h 05m
2 stops
£1,154Delta
Mon, 23 Mar - Wed, 8 Apr
KLM Logo
08:50 - 09:40
SOU
-
SCL
27h 50m
2 stops
KLM Logo
10:15 - 08:45
SCL
-
SOU
41h 30m
2 stops
£1,220KLM
Tue, 24 Mar - Thu, 9 Apr
KLM Logo
08:50 - 09:40
SOU
-
SCL
27h 50m
2 stops
KLM Logo
10:15 - 08:45
SCL
-
SOU
41h 30m
2 stops
£1,223KLM
Mon, 23 Mar - Thu, 9 Apr
KLM Logo
08:50 - 09:40
SOU
-
SCL
27h 50m
2 stops
KLM Logo
10:15 - 08:45
SCL
-
SOU
41h 30m
2 stops
£1,225KLM
Mon, 23 Mar - Thu, 9 Apr
Delta Logo
08:50 - 07:40
SOU
-
SCL
49h 50m
2 stops
Delta Logo
20:40 - 08:45
SCL
-
SOU
55h 05m
2 stops
£1,229Delta
Wed, 25 Mar - Wed, 8 Apr
Multiple Airlines Logo
19:55 - 01:30
SOU
-
SCL
32h 35m
3 stops
Multiple Airlines Logo
16:25 - 08:45
SCL
-
SOU
35h 20m
3 stops
£1,234Multiple Airlines
Mon, 23 Mar - Thu, 9 Apr
KLM Logo
09:25 - 11:05
SOU
-
SCL
28h 40m
2 stops
KLM Logo
10:15 - 08:45
SCL
-
SOU
41h 30m
2 stops
£1,284KLM
Sun, 22 Mar - Thu, 9 Apr
Delta Logo
17:30 - 07:40
SOU
-
SCL
65h 10m
2 stops
Delta Logo
20:40 - 08:45
SCL
-
SOU
55h 05m
2 stops
£1,304Delta
Sat, 21 Mar - Wed, 8 Apr
Delta Logo
17:45 - 07:40
SOU
-
SCL
40h 55m
2 stops
Delta Logo
20:40 - 16:50
SCL
-
SOU
39h 10m
2 stops
£1,329Delta
Sun, 22 Mar - Fri, 10 Apr

Delta flights from Southampton to Santiago

Our best Delta deals on Southampton to Santiago flight tickets
Delta
22 Mar
SOU17:45Southampton Eastleigh
40h 55m
2 stops
SCL07:40Santiago Arturo Merino Benitez
8 Apr
SCL20:40Santiago Arturo Merino Benitez
55h 05m
2 stops
SOU08:45Southampton Eastleigh
£1,104
Delta
23 Mar
SOU08:50Southampton Eastleigh
25h 50m
2 stops
SCL07:40Santiago Arturo Merino Benitez
8 Apr
SCL20:40Santiago Arturo Merino Benitez
55h 05m
2 stops
SOU08:45Southampton Eastleigh
£1,154
Delta
25 Mar
SOU08:50Southampton Eastleigh
49h 50m
2 stops
SCL07:40Santiago Arturo Merino Benitez
8 Apr
SCL20:40Santiago Arturo Merino Benitez
55h 05m
2 stops
SOU08:45Southampton Eastleigh
£1,229

KLM flights from Southampton to Santiago

Our best KLM deals on Southampton to Santiago flight tickets
KLM
24 Mar
SOU08:50Southampton Eastleigh
27h 50m
2 stops
SCL09:40Santiago Arturo Merino Benitez
9 Apr
SCL10:15Santiago Arturo Merino Benitez
41h 30m
2 stops
SOU08:45Southampton Eastleigh
£1,220
KLM
23 Mar
SOU08:50Southampton Eastleigh
27h 50m
2 stops
SCL09:40Santiago Arturo Merino Benitez
9 Apr
SCL10:15Santiago Arturo Merino Benitez
41h 30m
2 stops
SOU08:45Southampton Eastleigh
£1,223
KLM
23 Mar
SOU08:50Southampton Eastleigh
27h 50m
2 stops
SCL09:40Santiago Arturo Merino Benitez
9 Apr
SCL10:15Santiago Arturo Merino Benitez
41h 30m
2 stops
SOU08:45Southampton Eastleigh
£1,224

momondo Fare Finder

 
Customise your flight search to find flights from Southampton to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 279,928 searches. Data last updated 10 March 2026.
Use the filters below to find and compare flights from Southampton to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight

SouthamptonSantiago

SOU - SCL

SOUSCL

Southampton Eastleigh

Sun 22/3

17:45-07:40

2 stops40h 55m

Santiago Arturo Merino Benitez

Wed 8/4

20:40-08:45

2 stops55h 05m

£1,104

SouthamptonSantiago

SOU - SCL

SOUSCL

Southampton Eastleigh

Mon 23/3

08:50-07:40

2 stops25h 50m

Santiago Arturo Merino Benitez

Wed 8/4

20:40-08:45

2 stops55h 05m

£1,154

SouthamptonSantiago

SOU - SCL

SOUSCL

Southampton Eastleigh

Tue 24/3

08:50-09:40

2 stops27h 50m

Santiago Arturo Merino Benitez

Thu 9/4

10:15-08:45

2 stops41h 30m

£1,220

SouthamptonSantiago

SOU - SCL

SOUSCL

Southampton Eastleigh

Mon 23/3

08:50-09:40

2 stops27h 50m

Santiago Arturo Merino Benitez

Thu 9/4

10:15-08:45

2 stops41h 30m

£1,223

SouthamptonSantiago

SOU - SCL

SOUSCL

Southampton Eastleigh

Mon 23/3

08:50-09:40

2 stops27h 50m

Santiago Arturo Merino Benitez

Thu 9/4

10:15-08:45

2 stops41h 30m

£1,224

SouthamptonSantiago

SOU - SCL

SOUSCL

Southampton Eastleigh

Wed 25/3

08:50-07:40

2 stops49h 50m

Santiago Arturo Merino Benitez

Wed 8/4

20:40-08:45

2 stops55h 05m

£1,229
Fastest return journey

SouthamptonSantiago

SOU - SCL

SOUSCL

Southampton Eastleigh

Mon 23/3

19:55-01:30

3 stops32h 35m

Santiago Arturo Merino Benitez

Thu 9/4

16:25-08:45

3 stops35h 20m

£1,234

SouthamptonSantiago

SOU - SCL

SOUSCL

Southampton Eastleigh

Sun 22/3

09:25-11:05

2 stops28h 40m

Santiago Arturo Merino Benitez

Thu 9/4

10:15-08:45

2 stops41h 30m

£1,284

SouthamptonSantiago

SOU - SCL

SOUSCL

Southampton Eastleigh

Sat 21/3

17:30-07:40

2 stops65h 10m

Santiago Arturo Merino Benitez

Wed 8/4

20:40-08:45

2 stops55h 05m

£1,304

SouthamptonSantiago

SOU - SCL

SOUSCL

Southampton Eastleigh

Sun 22/3

17:45-07:40

2 stops40h 55m

Santiago Arturo Merino Benitez

Fri 10/4

20:40-16:50

2 stops39h 10m

£1,329

Flights are sorted by cheapest return flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Santiago from

How to get the cheapest flight ticket from Southampton to Santiago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Santiago?

The cheapest day to depart from Southampton to Santiago is on a Wednesday when prices can be found for as low as £931. Be sure to avoid booking your departure on a Saturday as prices are generally higher than usual. According to our data, the average ticket price to Santiago on Saturday is £1,077.

When to book flights from Southampton to Santiago

Are you open to changing your travel dates? Check out the ideal times to fly from Southampton to Santiago according to our flight data. Find out which month and days have the cheapest flights.
Estimated return price

Cheap Southampton to Santiago (SOU to SCL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Southampton to Santiago

Fastest flight time

27h 50m

Direct flights

None
The fastest flight from Southampton to Santiago takes 27h 50m
There are no direct flights from Southampton to Santiago. There are no popular flight routes from Southampton to Santiago.
Search flight deals

  • How far is Southampton Eastleigh to Santiago Arturo Merino Benitez by plane?

    Santiago Arturo Merino Benitez is 7178.6 mi away from Southampton Eastleigh. In terms of flight time, this usually takes a little over 27h 50m.

  • When did momondo last update prices for flights from Southampton Eastleigh Airport to Santiago Arturo Merino Benitez Airport?

    Prices for flights from Southampton Eastleigh Airport to Santiago Arturo Merino Benitez Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Southampton Eastleigh Airport to Santiago Arturo Merino Benitez Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Southampton Eastleigh Airport to Santiago Arturo Merino Benitez Airport.

  • What documentation or ID do you need to fly to Santiago Arturo Merino Benitez Airport?

    The travel and health documents required for your trip to Santiago Arturo Merino Benitez Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Santiago Arturo Merino Benitez Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Travelling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Santa Cruz
Valparaíso

Why use momondo?

Why should I use momondo to find a flight deal from Southampton to Santiago?

Finding the right flight to Santiago from Southampton is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santiago quick and easy, saving you time and money.

Can I find flights from Southampton to Santiago with flexible booking policies on momondo?

Flights from Southampton to Santiago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Southampton to Santiago?

momondo provides multiple filters to help you find the best flight to Santiago from Southampton. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Southampton to Santiago right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santiago from Southampton. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Santiago trip

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