Cheap flights from Chicago O'Hare Intl Airport to London from £254

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Chicago to Southampton for you.

Flights from Chicago to Southampton with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

Once you have performed a search for Chicago to Southampton flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

If you are not ready to book a flight from Chicago to Southampton now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Southampton and let you know when they change.