Which airlines fly to San Francisco?

Virgin Atlantic, British Airways and Lufthansa are the top three most popular airlines that fly to San Francisco from Southampton according to our data. Virgin Atlantic is the first choice among our users, with 36% of people opting to fly with this airline when travelling to San Francisco. Keep in mind that there are 19 different airlines that fly to San Francisco on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Southampton Eastleigh to San Francisco?

KLM and British Airways are the most popular carriers operating from Southampton Eastleigh to San Francisco

When did momondo last update prices for flights from Southampton Eastleigh Airport to San Francisco Airport?

Prices for flights from Southampton Eastleigh Airport to San Francisco Airport are refreshed on a daily basis.

How old do you have to be to fly from Southampton Eastleigh Airport to San Francisco Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Southampton Eastleigh Airport to San Francisco Airport.

What documentation or ID do you need to fly to San Francisco Airport?

The travel and health documents required for your trip to San Francisco Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at San Francisco Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

£366 Cheap Flights from Southampton to San Francisco in 2026/27

Find the cheapest flights from Southampton to San Francisco

Return

One-way

Last minute

Cheap return flights

Enter your travel dates to find the best prices.

17:35 - 12:45SOU Southampton Eastleigh-SFO San Francisco

26h 10m1 stop Amsterdam Schiphol

13:50 - 16:50SFO San Francisco-SOU Southampton Eastleigh

19h 00m1 stop Amsterdam Schiphol

£652KLM

Tue, 27 Oct - Fri, 27 Nov

17:35 - 11:45SOU Southampton Eastleigh-SFO San Francisco

26h 10m1 stop Amsterdam Schiphol

12:17 - 17:05SFO San Francisco-SOU Southampton Eastleigh

20h 48m2 stops Detroit Metropolitan Wayne County Amsterdam Schiphol

£655KLM

Thu, 26 Nov - Thu, 3 Dec

08:40 - 22:38SOU Southampton Eastleigh-SFO San Francisco

20h 58m2 stops Amsterdam Schiphol Detroit Metropolitan Wayne County

13:50 - 16:50SFO San Francisco-SOU Southampton Eastleigh

19h 00m1 stop Amsterdam Schiphol

£659KLM

Tue, 27 Oct - Fri, 27 Nov

08:40 - 20:32SOU Southampton Eastleigh-SFO San Francisco

19h 52m2 stops Amsterdam Schiphol Minneapolis St Paul

12:17 - 17:05SFO San Francisco-SOU Southampton Eastleigh

20h 48m2 stops Detroit Metropolitan Wayne County Amsterdam Schiphol

£662KLM

Thu, 26 Nov - Thu, 3 Dec

17:20 - 11:45SOU Southampton Eastleigh-SFO San Francisco

26h 25m1 stop Amsterdam Schiphol

07:00 - 08:55SFO San Francisco-SOU Southampton Eastleigh

17h 55m2 stops New York John F Kennedy Intl Amsterdam Schiphol

£666Virgin Atlantic

Sat, 7 Nov - Sat, 14 Nov

17:20 - 11:45SOU Southampton Eastleigh-SFO San Francisco

26h 25m1 stop Amsterdam Schiphol

09:00 - 16:50SFO San Francisco-SOU Southampton Eastleigh

23h 50m2 stops New York John F Kennedy Intl Amsterdam Schiphol

£668Delta

Sat, 7 Nov - Sat, 14 Nov

08:40 - 22:38SOU Southampton Eastleigh-SFO San Francisco

20h 58m2 stops Amsterdam Schiphol Detroit Metropolitan Wayne County

12:10 - 16:50SFO San Francisco-SOU Southampton Eastleigh

20h 40m2 stops Minneapolis St Paul Amsterdam Schiphol

£672Delta

Tue, 27 Oct - Fri, 27 Nov

17:20 - 11:45SOU Southampton Eastleigh-SFO San Francisco

26h 25m1 stop Amsterdam Schiphol

13:50 - 08:10SFO San Francisco-SOU Southampton Eastleigh

34h 20m1 stop Amsterdam Schiphol

£690Virgin Atlantic

Sat, 7 Nov - Sat, 14 Nov

17:35 - 11:45SOU Southampton Eastleigh-SFO San Francisco

26h 10m1 stop Amsterdam Schiphol

13:45 - 17:00SFO San Francisco-SOU Southampton Eastleigh

19h 15m1 stop Amsterdam Schiphol

£697Delta

Tue, 17 Nov - Wed, 14 Apr

17:35 - 12:45SOU Southampton Eastleigh-SFO San Francisco

26h 10m1 stop Amsterdam Schiphol

13:50 - 08:55SFO San Francisco-SOU Southampton Eastleigh

35h 05m1 stop Amsterdam Schiphol

£698Delta

Tue, 27 Oct - Fri, 8 Jan

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KLM flights from Southampton to San Francisco

Our best KLM deals on Southampton to San Francisco flight tickets

KLM

27 Oct

SOU17:35Southampton Eastleigh

26h 10m

1 stop

SFO12:45San Francisco

27 Nov

SFO13:50San Francisco

19h 00m

1 stop

SOU16:50Southampton Eastleigh

£652

KLM

26 Nov

SOU17:35Southampton Eastleigh

26h 10m

1 stop

SFO11:45San Francisco

3 Dec

SFO12:17San Francisco

20h 48m

2 stops

SOU17:05Southampton Eastleigh

£655

KLM

27 Oct

SOU08:40Southampton Eastleigh

20h 58m

2 stops

SFO22:38San Francisco

27 Nov

SFO13:50San Francisco

19h 00m

1 stop

SOU16:50Southampton Eastleigh

£659

Virgin Atlantic flights from Southampton to San Francisco

Our best Virgin Atlantic deals on Southampton to San Francisco flight tickets

Virgin Atlantic

7 Nov

SOU17:20Southampton Eastleigh

26h 25m

1 stop

SFO11:45San Francisco

14 Nov

SFO07:00San Francisco

17h 55m

2 stops

SOU08:55Southampton Eastleigh

£666

Virgin Atlantic

7 Nov

SOU17:20Southampton Eastleigh

26h 25m

1 stop

SFO11:45San Francisco

14 Nov

SFO13:50San Francisco

34h 20m

1 stop

SOU08:10Southampton Eastleigh

£690

momondo Fare Finder

Use the filters below to find and compare flights from Southampton to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight

SouthamptonSan Francisco

SOU Southampton Eastleigh - SFO San Francisco

SOUSFO

Southampton Eastleigh

Tue 27/10

17:35-12:45

1 stop26h 10m

San Francisco

Fri 27/11

13:50-16:50

1 stop19h 00m

£652

SouthamptonSan Francisco

SOU Southampton Eastleigh - SFO San Francisco

SOUSFO

Southampton Eastleigh

Thu 26/11

17:35-11:45

1 stop26h 10m

San Francisco

Thu 3/12

12:17-17:05

2 stops20h 48m

£655

Fastest return journey

SouthamptonSan Francisco

SOU Southampton Eastleigh - SFO San Francisco

SOUSFO

Southampton Eastleigh

Tue 27/10

08:40-22:38

2 stops20h 58m

San Francisco

Fri 27/11

13:50-16:50

1 stop19h 00m

£659

SouthamptonSan Francisco

SOU Southampton Eastleigh - SFO San Francisco

SOUSFO

Southampton Eastleigh

Thu 26/11

08:40-20:32

2 stops19h 52m

San Francisco

Thu 3/12

12:17-17:05

2 stops20h 48m

£662

SouthamptonSan Francisco

SOU Southampton Eastleigh - SFO San Francisco

SOUSFO

Southampton Eastleigh

Sat 7/11

17:20-11:45

1 stop26h 25m

San Francisco

Sat 14/11

07:00-08:55

2 stops17h 55m

£666

SouthamptonSan Francisco

SOU Southampton Eastleigh - SFO San Francisco

SOUSFO

Southampton Eastleigh

Sat 7/11

17:20-11:45

1 stop26h 25m

San Francisco

Sat 14/11

09:00-16:50

2 stops23h 50m

£668

SouthamptonSan Francisco

SOU Southampton Eastleigh - SFO San Francisco

SOUSFO

Southampton Eastleigh

Tue 27/10

08:40-22:38

2 stops20h 58m

San Francisco

Fri 27/11

12:10-16:50

2 stops20h 40m

£672

SouthamptonSan Francisco

SOU Southampton Eastleigh - SFO San Francisco

SOUSFO

Southampton Eastleigh

Sat 7/11

17:20-11:45

1 stop26h 25m

San Francisco

Sat 14/11

13:50-08:10

1 stop34h 20m

£690

SouthamptonSan Francisco

SOU Southampton Eastleigh - SFO San Francisco

SOUSFO

Southampton Eastleigh

Tue 17/11

17:35-11:45

1 stop26h 10m

San Francisco

Wed 14/4

13:45-17:00

1 stop19h 15m

£697

SouthamptonSan Francisco

SOU Southampton Eastleigh - SFO San Francisco

SOUSFO

Southampton Eastleigh

Tue 27/10

17:35-12:45

1 stop26h 10m

San Francisco

Fri 8/1

13:50-08:55

1 stop35h 05m

£698

Flights are sorted by cheapest return flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Southampton to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart on your flight to San Francisco is on a Wednesday when prices can be found for as low as £584. This is often the case because there is less demand to fly during this day of the week. Flights from Southampton to San Francisco on a Sunday will generally be more expensive and average around £672. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to San Francisco?

Our most recent data shows that the best time of day to fly to San Francisco is in the morning. Flights from Southampton to San Francisco during this time can be as low as £610. Try not to purchase tickets in the afternoon because they tend to be around £642. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Southampton to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Southampton to San Francisco according to our flight data. Find out which month and days have the cheapest flights.

Estimated return price

Cheap Southampton to San Francisco (SOU to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Southampton to San Francisco

Best price found	£366
Fastest flight time	26h 10m
Direct flights	None

The best one-way flight to San Francisco from Southampton in the past 72 hours is £366. The best return flight deal from Southampton to San Francisco found on momondo in the last 72 hours is £652.

The fastest flight from Southampton to San Francisco takes 26h 10m

There are no direct flights from Southampton to San Francisco. There are no popular flight routes from Southampton to San Francisco.

Search flight deals

Frequently asked questions about flying from Southampton to San Francisco

How far is Southampton Eastleigh to San Francisco by plane?
A flight from Southampton Eastleigh to San Francisco will travel around 5341.3 mi. By plane, this route typically takes 26h 10m.
When did momondo last update prices for flights from Southampton Eastleigh Airport to San Francisco Airport?
Prices for flights from Southampton Eastleigh Airport to San Francisco Airport are refreshed on a daily basis.
How old do you have to be to fly from Southampton Eastleigh Airport to San Francisco Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Southampton Eastleigh Airport to San Francisco Airport.
What documentation or ID do you need to fly to San Francisco Airport?
The travel and health documents required for your trip to San Francisco Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at San Francisco Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

South San Francisco

Carmel-by-the-Sea

Santa Cruz

Sunnyvale

Calistoga

Rohnert Park

Windsor

Burlingame

Big Sur

Belmont

Sausalito

Pacific Grove

Aptos

Mill Valley

Palo Alto

Newark

Campbell

Seaside

Roseville

Novato

Why use momondo?

Why should I use momondo to find a flight deal from Southampton to San Francisco?

It is quick and easy to find Southampton to San Francisco flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to San Francisco that suits you.

Can I find flights from Southampton to San Francisco with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Francisco from Southampton which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Southampton to San Francisco?

Once all potential Southampton to San Francisco flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Southampton to San Francisco right now. Can momondo alert me if prices change?

Price alerts on flights to San Francisco from Southampton are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.