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Cheap flights from Southampton to San Francisco from £420

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Southampton to San Francisco departing on 19/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap return flights

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Virgin Atlantic Logo
08:50 - 11:50SOU-SFO
35h 00m1 stop
Virgin Atlantic Logo
13:55 - 08:20SFO-SOU
34h 25m1 stop
£485Virgin Atlantic
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Thu, 4 Dec - Tue, 9 Dec
Delta Logo
08:50 - 11:50SOU-SFO
35h 00m1 stop
Delta Logo
22:55 - 08:20SFO-SOU
25h 25m2 stops
£498Delta
Find Deal
Thu, 4 Dec - Tue, 9 Dec
KLM Logo
18:05 - 13:25SOU-SFO
27h 20m2 stops
KLM Logo
13:55 - 08:10SFO-SOU
34h 15m1 stop
£615KLM
Find Deal
Sun, 21 Dec - Sun, 28 Dec
KLM Logo
18:05 - 13:25SOU-SFO
27h 20m2 stops
KLM Logo
15:40 - 17:25SFO-SOU
17h 45m2 stops
£634KLM
Find Deal
Sun, 21 Dec - Sun, 28 Dec
Multiple Airlines Logo
17:30 - 13:25SOU-SFO
27h 55m2 stops
Multiple Airlines Logo
19:20 - 17:25SFO-SOU
38h 05m2 stops
£862Multiple Airlines
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Sat, 20 Dec - Sat, 27 Dec
Aer Lingus Logo
09:30 - 15:35SOU-SFO
14h 05m1 stop
Aer Lingus Logo
17:20 - 19:40SFO-SOU
18h 20m1 stop
£910Aer Lingus
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Sat, 20 Dec - Sat, 27 Dec
British Airways Logo
19:55 - 18:45SOU-SFO
30h 50m2 stops
British Airways Logo
20:40 - 09:00SFO-SOU
28h 20m2 stops
£1,015British Airways
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Thu, 20 Nov - Thu, 27 Nov
Multiple Airlines Logo
18:05 - 16:05SOU-SFO
30h 00m2 stops
Multiple Airlines Logo
12:00 - 17:00SFO-SOU
21h 00m3 stops
£1,035Multiple Airlines
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Thu, 4 Dec - Tue, 9 Dec
Aer Lingus Logo
09:30 - 22:58SOU-SFO
21h 28m2 stops
Aer Lingus Logo
20:40 - 08:45SFO-SOU
28h 05m2 stops
£1,039Aer Lingus
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Sat, 20 Dec - Sat, 27 Dec
British Airways Logo
18:25 - 15:00SOU-SFO
28h 35m3 stops
British Airways Logo
20:40 - 11:55SFO-SOU
31h 15m2 stops
£1,110British Airways
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Sun, 21 Dec - Sun, 28 Dec

KLM flights from Southampton to San Francisco

Our best KLM deals on Southampton to San Francisco flight tickets
KLM
21 Dec
SOU18:05Southampton Eastleigh
27h 20m
2 stops
SFO13:25San Francisco
28 Dec
SFO13:55San Francisco
34h 15m
1 stop
SOU08:10Southampton Eastleigh
£615
Find similar
KLM
21 Dec
SOU18:05Southampton Eastleigh
27h 20m
2 stops
SFO13:25San Francisco
28 Dec
SFO15:40San Francisco
17h 45m
2 stops
SOU17:25Southampton Eastleigh
£634
Find similar
KLM
20 Dec
SOU17:30Southampton Eastleigh
27h 55m
2 stops
SFO13:25San Francisco
27 Dec
SFO13:55San Francisco
34h 15m
1 stop
SOU08:10Southampton Eastleigh
£905
Find similar

British Airways flights from Southampton to San Francisco

Our best British Airways deals on Southampton to San Francisco flight tickets
British Airways
20 Nov
SOU19:55Southampton Eastleigh
30h 50m
2 stops
SFO18:45San Francisco
27 Nov
SFO20:40San Francisco
28h 20m
2 stops
SOU09:00Southampton Eastleigh
£1,015
Find similar
British Airways
21 Dec
SOU18:25Southampton Eastleigh
28h 35m
3 stops
SFO15:00San Francisco
28 Dec
SFO20:40San Francisco
31h 15m
2 stops
SOU11:55Southampton Eastleigh
£1,110
Find similar
British Airways
12 Nov
SOU19:55Southampton Eastleigh
27h 05m
2 stops
SFO15:00San Francisco
13 Nov
SFO17:30San Francisco
18h 00m
2 stops
SOU19:30Southampton Eastleigh
£3,044
Find similar

momondo Fare Finder

 
Customise your flight search to find flights from Southampton to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 279,928 searches. Data last updated 7 November 2025.
Use the filters below to find and compare flights from Southampton to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SouthamptonSan Francisco

SOU - SFO

SOUSFO

Southampton Eastleigh

Thu 4/12

08:50-11:50

1 stop35h 00m

San Francisco

Tue 9/12

13:55-08:20

1 stop34h 25m

£485

SouthamptonSan Francisco

SOU - SFO

SOUSFO

Southampton Eastleigh

Thu 4/12

08:50-11:50

1 stop35h 00m

San Francisco

Tue 9/12

22:55-08:20

2 stops25h 25m

£498

SouthamptonSan Francisco

SOU - SFO

SOUSFO

Southampton Eastleigh

Sun 21/12

18:05-13:25

2 stops27h 20m

San Francisco

Sun 28/12

13:55-08:10

1 stop34h 15m

£615

SouthamptonSan Francisco

SOU - SFO

SOUSFO

Southampton Eastleigh

Sun 21/12

18:05-13:25

2 stops27h 20m

San Francisco

Sun 28/12

15:40-17:25

2 stops17h 45m

£634

SouthamptonSan Francisco

SOU - SFO

SOUSFO

Southampton Eastleigh

Sat 20/12

17:30-13:25

2 stops27h 55m

San Francisco

Sat 27/12

19:20-17:25

2 stops38h 05m

£862

SouthamptonSan Francisco

SOU - SFO

SOUSFO

Southampton Eastleigh

Sat 20/12

09:30-15:35

1 stop14h 05m

San Francisco

Sat 27/12

17:20-19:40

1 stop18h 20m

£910

SouthamptonSan Francisco

SOU - SFO

SOUSFO

Southampton Eastleigh

Thu 20/11

19:55-18:45

2 stops30h 50m

San Francisco

Thu 27/11

20:40-09:00

2 stops28h 20m

£1,015

SouthamptonSan Francisco

SOU - SFO

SOUSFO

Southampton Eastleigh

Thu 4/12

18:05-16:05

2 stops30h 00m

San Francisco

Tue 9/12

12:00-17:00

3 stops21h 00m

£1,035

SouthamptonSan Francisco

SOU - SFO

SOUSFO

Southampton Eastleigh

Sat 20/12

09:30-22:58

2 stops21h 28m

San Francisco

Sat 27/12

20:40-08:45

2 stops28h 05m

£1,039

SouthamptonSan Francisco

SOU - SFO

SOUSFO

Southampton Eastleigh

Sun 21/12

18:25-15:00

3 stops28h 35m

San Francisco

Sun 28/12

20:40-11:55

2 stops31h 15m

£1,110

Flights are sorted by cheapest return flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to San Francisco from

How to get the cheapest flight ticket from Southampton to San Francisco

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to San Francisco?

The cheapest day to depart on your flight to San Francisco is on a Thursday when prices can be found for as low as £596. This is often the case because there is less demand to fly during this day of the week. Flights from Southampton to San Francisco on a Sunday will generally be more expensive and average around £693. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to San Francisco?

Our most recent data shows that the best time of day to fly to San Francisco is in the evening. Flights from Southampton to San Francisco during this time can be as low as £491. Try not to purchase tickets at midday because they tend to be around £986. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Southampton to San Francisco

Are you open to changing your travel dates? Check out the ideal times to fly from Southampton to San Francisco according to our flight data. Find out which month and days have the cheapest flights.
Estimated return price

Cheap Southampton to San Francisco (SOU to SFO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Southampton to San Francisco

Direct flights

None
There are no direct flights from Southampton to San Francisco. There are no popular flight routes from Southampton to San Francisco.
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  • How far is Southampton Eastleigh to San Francisco by plane?

    A flight from Southampton Eastleigh to San Francisco will travel around 5341.1 mi. By plane, this route typically takes 14h 05m.

  • When did momondo last update prices for flights from Southampton Eastleigh Airport to San Francisco Airport?

    Prices for flights from Southampton Eastleigh Airport to San Francisco Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Southampton Eastleigh Airport to San Francisco Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Southampton Eastleigh Airport to San Francisco Airport.

  • What documentation or ID do you need to fly to San Francisco Airport?

    The travel and health documents required for your trip to San Francisco Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at San Francisco Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Travelling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Carmel-by-the-Sea
Santa Clara
Seaside
Big Sur
Rohnert Park
Sunnyvale
San Ramon
South San Francisco
Capitola
Campbell
Palo Alto
Sausalito
San Bruno
Woodland
Santa Cruz
Redwood City
Burlingame
Modesto
Aptos
Fremont

Why use momondo?

Why should I use momondo to find a flight deal from Southampton to San Francisco?

It is quick and easy to find Southampton to San Francisco flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to San Francisco that suits you.

Can I find flights from Southampton to San Francisco with flexible booking policies on momondo?

momondo does allow users to show only those flights to San Francisco from Southampton which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Southampton to San Francisco?

Once all potential Southampton to San Francisco flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Southampton to San Francisco right now. Can momondo alert me if prices change?

Price alerts on flights to San Francisco from Southampton are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your San Francisco trip

We make it super easy to schedule, organise and travel with friends or family. Trips is free – and available to use no matter where you book.
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